Trasplante de microbiota Estado de la investigación y recursos

Transplante de microbiota,
¿en qué etapa del desarrollo está el mundo medico?

En este documento traté de resumir algo de la frondosa documentación y recursos sobre Transplante de Microbiota en el mundo. Este es un tema muy seguido por la comunidad médica mundial por las interesantes perspectivas que su desarrollo ofrece.

Food and Drug administration - FDA

Hasta Julio del 2013 para hacer un trasplante de microbiota había que presentar un requerimiento para autorización, desde esa fecha se puede efectuar en Estados Unidos sin permiso, se puede ver en el siguiente artículo.
(http://seattletimes.com/html/localnews/2022132117_cdifftransplantxml.html) y http://projectmillennial.org/2013/06/19/the-fda-just-made-it-easier-for-physicians-to-treat-c-diff-cheaply-and-effectively-with-poop/

Ensayos clínicos en curso en Estados Unidos

http://clinicaltrials.gov/ct2/results?term=fecal+transplantation&recr=Open&cntry1=NA%3AUS

Simposio Madrid

Congreso sobre Microbiota y trasplantes hecho en Madrid en Febrero 2013
Programa: http://summit-registration.gutmicrobiotaforhealth.com/data/program-GMH-2013.pdf

Más simposios pueden ser seguidos en http://www.gutmicrobiotaforhealth.com/

 

Bibliografía

* Transplante de Microbiota

American Gastroenterological Association (website)

FMT Science (website)

FMT Stands Up To Antibiotics in Cost-Effectiveness Model (2014)

Fecal microbiota transplantation: effectiveness, complexities, and lingering concerns (2014)

Fecal microbiota transplantation: facts and controversies (2014)

Fecal Transplant an Option Even in the Immunocompromised (2013)

Microbiota Take 4 months to Colonise after FMT for Recurrent Clostridium difficile Infection (2013)

New Evidence Reveals Impact of Fecal Transplantation upon Gut Flora and Digestive Health (2013)

Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease? (2013)

Therapeutic Potential of Fecal Microbiota Transplantation  (2013)

Fecal microbiota transplantation and donor standardization (2013)

Fecal microbiota transplantation: past, present and future (2013)

Fame and future of fecal transplantations (2013)

Fecal Microbiota Transplant: We Know Its History, but Can We Predict Its Future?  (2013)

IDSA: Oral Ingestion Viable for Fecal Microbiome Transplant (2013)

Fecal Microbiota Transplant Using Frozen Inoculum Effective for Recurring Clostridium difficile (2013)

Fecal Microbiota Transplantation - Techniques, Applications, and Issues (2012)

FMT techniques, applications and issues (2012)

Fecal microbiota transplantation and emerging applications (2011)

Durable alteration of the colonic microbiota by the administration of donor fecal flora (2010)

Bacteriotherapy using fecal flora: Toying with Human Motions  (2004)

* Microbiota, Transplante - Enfermedad Inflamatoria de Intestino (Crohn & CU)

 Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies (2014)

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a deficient commensal bacteria implicated in Crohn’s disease (2014)

Increased Prevalence of Methanosphaera stadtmanae in Inflammatory Bowel Diseases (2014)

Fecal transplantation in patients with moderately to severely chronic active ulcerative colitis (2014)

A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis (2013)

FMT for severe enterocolonic fistulizing Crohns Disease (2013)

Safety, Tolerability, and Clinical Response After Fecal Transplantation in Children and Young Adults With Ulcerative Colitis (2013)

Experimental fecal transplants could revolutionize treatment of bowel diseases (2013)

Fecal Transplant Shown To Treat Inflammatory Bowel Disease In Children (2013)

The microbiota and inflammatory bowel disease: Insights from animal models (2013)

Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases (2013)

Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia colileads to chronic inflammation and intestinal fibrosis (2014)

The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease? (2013)

The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease (2013)

Brain-gut interactions in inflammatory bowel disease (2013)

Colon Cancer and IBD: Potential Links to Microbiota, Race (2013)

Study identifies distinct microbiome in Crohn’s intestinal submucosa (2013)

Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota Transplantation. (2013)

Dysfunctional gut microbiota closely linked to range of health issues (2013)

Bacterial molecules may prevent inflammatory bowel disease (2013)

Systematic review: fecal microbiota transplantation in the management of inflammatory bowel disease (2012)

Does our food (environment) change our gut microbiome (‘in-vironment’): a potential role for inflammatory bowel disease? (2012)

The microbiome and inflammatory bowel disease: is there a therapeutic role for fecal microbiota transplantation? (2012)

Review article: fecal transplantation therapy for gastrointestinal disease (2011)

Colonic Microbiota and Crohns Disease & FUT2  Genotype (2011)

Antibiotic use and inflammatory bowel diseases in childhood (2010)

Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota (2010)

FMT in UC: Spotlight on Patients’ E‘motions’ (2011?)

Treatment of Ulcerative Colitis using fecal bacteriotherapy (2003

 

Médicos y Centros que aplican transplante de Microbiota -

Médicos

La mayoría exclusivamente para casos de Clostridium difficile

Australia:

Dr Sanjay Nandurkar, Box Hill, VIC

Dr Paul Froomes, Essendon, VIC

Europa:

Dr Josbert Keller, Haga Teaching Hospital, The Hague, Netherlands

Ryhov Hospital Jönköping, Sweden

Prof. Gerhard Rogler, University Hospital, Zurich, Switzerland

Dr. Eero Mattila, Helsinki University Central Hospital, Finland

Canada:

Dr Christine Lee Hamilton Hospital in Hamilton, Ontario

Thomas Louie, MD, University of Calgary

Dr. David Kreaden, Toronto, Canada

USA:

Eugene F Yen MD , Evanston, IL

Arnab Ray MD, New Orleans, LA

Steve Freeman, MD, University of Colorado 

F. Lyone Hochman, MD, Houston, TX

Satish M Rao, M.D. Augusta, GA

Ohio Hospitals 

Maria Oliva-Hemker, M.D. John Hopkins Children’s Hospital Baltimore, MD

Lawrence Brandt, New York, NY

Jonathan Goldstein MD, Rochester, NY

Shelley Gordon MD, California Pacific Medical

Michael J. Docktor, Boston MD (IBD Pediatrician)

David A Johnson MD, Norfolk, VA

Tim Rubin MD, Minnesota

Los Angeles Colon and Rectal Surgical Associates 

Colleen Kelly MD. Rhode Island

Sudhir K. Dutta MD, Baltimore

Alexander Khoruts MD, Minneapolis

Paul F Schleinitz MD, Oregon

Gary Griglione, MD Madison, Wisconsin

Jackson Seigelbaum, MD, Gastroenterology Harrisburg, PI 

Robert W. Schuman MD, West Orange, Nj

Ellen Scherl, MD, NY NY

David Rubin, MD, Chicago, IL

Mark Mellow MD, Oklahoma City

Joseph Brasco MD, Huntsville, AL

Susan Edwards DHMC LebanonNH  (children)

Alister George MD, Thousand Oaks,CA 

Douglas Wolf St.Joseph, Atlanta

Mayo Clinic in Phoenix AZ 

Mayo Clinic Minnesota

Andrew Zwick and Lawrence Fiedler Boca Raton, FL 

Sovi Joseph, Fawcett Memorial Hospital, Port Charlotte, FL

Gastroenterology Consultants, Reno, NV

Lisa B Malter, MD New York University School of Medicine 

Darrell Pardi, MD / Sahil Khanna, MMS Mayo Clinic, Rochester, MN

Martin H Poleski, MD, CM Durham, NC 

David L Suskind MD, Seattle, WA (pediatrics)

Christina M Surawicz, MD Seattle, WA
 (pediatrics)

Mark Allen  (cdiff only), Kansas City, MO

Michael Vaezi, MD, Nashville, TN

Jack Bragg and Dr. Ghassan Hammoud, University of Missouri Health Center, Columbia, MO

Andrew Weinberg MD, Gilbert AZ

Neil Stollman MD, Oakland, CA

Barry Schneider MD, Charlotte, NC

Daniel Hampton MD, Las Cruces, NM, USA

Michael B Edmond MD, Richmond, VA 

Maria Oliva-Hemka MD, Baltimore MD  (Paediatrician) 

Katherine A. Kosche, MD, Pembroke Pines, FL

 Clínicas donde se realizan trasplantes

Australia

The Centre for Digestive Diseases, Sydney, NSW

USA

The Bright Medicine Clinic, Portland, Oregon

RDS Infusions, Tampa FL

Inglaterra

The Taymount Clinic for Digestive Health and their brochure.

Europa Continental

Ninguna aún